Makers › Physician / Medical Master
Tu Youyou
Head of the antimalarial research group at the Institute of Chinese Materia Medica of the Academy of Traditional Chinese Medicine, whose group turned to low-temperature ether extraction of sweet wormwood in 1971 and in November 1972 separated the antimalarial crystal later named artemisinin.
Mural of the event “Artemisinin from Sweet Wormwood”, which this person took part in.
In 1967 a nationwide antimalarial project, 523, was launched, with more than 500 researchers from more than 60 institutions. In 1969 the Institute of Chinese Materia Medica of the Academy of Traditional Chinese Medicine took on the task of finding antimalarial herbal drugs; its group read the medical literature and folk prescriptions and compiled about 640 prescriptions. Prompted by the Handbook of Prescriptions for Emergencies, the group moved to low-temperature extraction of sweet wormwood with ether, which boils at a low temperature. On 4 October 1971 the ether neutral extract numbered 191 inhibited the malaria parasite by 100 per cent in tests; in 1972 the group ran a clinical check on Hainan, and in November a crystal with antimalarial effect, later called artemisinin, was separated on a silica column. Institutions in Yunnan, Shandong, Guangzhou and the Institute of Biophysics of the Chinese Academy of Sciences also worked on extraction, clinical studies and structure.
Also known as Youyou Tu
Tu Youyou was born in 1930 and worked at the Institute of Chinese Materia Medica of the Academy of Traditional Chinese Medicine (now the China Academy of Chinese Medical Sciences). In 1967 a nationwide project to find new antimalarial drugs, code-named 523, began; in January 1969 the Academy gave its task of studying antimalarial herbal drugs to the Institute, and she became head of its antimalarial research group. In 1971, prompted by a passage in the Eastern Jin physician Ge Hong's Handbook of Prescriptions for Emergencies, it turned to low-temperature extraction of sweet wormwood with ether, and on 4 October of that year the ether neutral extract numbered 191 inhibited the malaria parasite by 100 per cent. In 1972 the group ran a clinical check at Changjiang on Hainan, and in November that year it separated an antimalarial crystal on a silica gel column, later named artemisinin. In October 1986 artemisinin and its suppositories received a new-drug certificate. On 5 October 2015 the Nobel Assembly announced that one half of that year's Nobel Prize in Physiology or Medicine was awarded to her "for her discoveries concerning a novel therapy against Malaria".
Life and times
- UnknownBorn
Modern Era1930 CE–
- 1971Artemisinin from Sweet Wormwood
Took partOn 4 October 1971 the ether neutral extract of sweet wormwood numbered 191 inhibited the malaria parasite by 100 per cent in tests, and in November 1972 an antimalarial crystal, later called artemisinin, was separated from it.
- UnknownDied